Natural Product Inspired Novel Antimalarials

The Department of Chemistry is excited to welcome PSU's own Research Assistant Professor, Dr. Papireddy Kancharla, in their ongoing seminar series! Learn More

Abstract:

"Over the past several decades, natural products have been the most successful source of potential drugs to combat many infectious diseases. Notably, they have provided some of the best antimalarials known to date, such as quinine and artemisinin, isolated from Cinchona species and Artemisia annua, respectively. Many of these natural products provided inspiration and template toward the design and development of various antimalarials currently in clinical use or under development. Recently, our efforts focused on the biosynthesis and synthesis of various novel antimalarial natural products. A rigorous structural optimization process has expanded our chemical library, and more importantly, produced lead candidates with significantly improved efficacy and safety profiles."