Department of Chemistry

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Kancharla Lab Publications and Patents

Publications

  1. Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan A, Garcia L, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, Deluca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chimong A, Cui L, Vega-Rodriguez J, Okitwi M, Kreutzfeld O, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, McFadden GI, Goodman CD, Probst AS, Nilsen A, Catteruccia F, Rosenthal PJ, Riscoe MK, Cooper R, Roth A, Kelly JX. Potent acridone antimalarial against all three life stages of Plasmodium. Res Sq [Preprint], 2025. Jun 27, 2025.
  2. Dodean RA, Li Y, Zhang X, Kumar A, Pou S, Winter RW, Liebman KM, Zakharov LN, Caridha D, Madejczyk MS, Vuong C, DeLuca J, Chin G, Kudyba K, McEnearney S, Jin X, Dennis WE, Chetree R, Blount C, Pannone K, Dinh HT, Mdaki K, Leed S, Lee PJ, Roth A, Kancharla P, Kelly JX. Acridone prodrugs with enhanced dual-stage antimalarial efficacy. ACS Medicinal Chemistry Letters, 2025, 16, 1383–1390, June 05, 2025.
  3. Kumar A, Li Y, Zhang X, Jin X, Dennis WE, Chetree R, Blount C, Caridha D, Madejczyk MS, Lee PJ, Pannone K, DeLuca J, Vuong C, Leed S, Dinh HT, Mdaki K, Mahato R, Sen P, Mondal T, Phukan K, Saha A, Chim-Ong A, Cui L, Valmon R, Chithanna S, Dodean RA, Peyton DH, Orena S, Assimwe J, Tibagambirwa I, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Chenu E, Duffy J, Roth A, Reynolds KA, Kelly JX, Kancharla P. Optimization of tambjamines active against multiple stages of malaria parasites. Journal of Medicinal Chemistry, 2025, 68, 11746–11785. June 01, 2025.
  4. Farrell SN, Cozijnsen A, Mollard V, Kancharla P, Dodean RA, Kelly JX, McFadden GI, Goodman CD. Identifying antimalarials that disrupt malaria parasite transmission when fed to the mosquito. International Journal for Parasitology, 2025, 55, 603–613. May 29, 2025.
  5. Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Pou S, Winter RW, Liebman KM, Williams R, Kumar A, Chim-Ong A, Cui L, Orena S, Assimwe J, Tibagambirwa I, Byaruhanga O, Angutoko P, Legac J, Kreutzfeld O, Rosenthal PJ, Cooper RA, Nilsen A, Riscoe MK, Roth A, Kancharla P, Kelly JX. Development of next-generation antimalarial acridones with radical cure potential. Journal of Medicinal Chemistry 2025, 68, 8817–8840. April 3, 2025.
  6. Chourasiya M, Vikram VN, Kancharla P, Kant R, Tadigoppula N. Ruthenium(II)-catalyzed construction of 2,3-disubstituted benzo[b]thiophene-1,1-dioxides and naphtho[1,2-b]thiophene-1,1-dioxides. Organic Letters, 2025, 27, 5170–5175. May 13, 2025
  7. Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Tambjamines as fast-acting multistage antimalarials. ACS Infect Diseases, 2024, 10, 4291–4300. November 11, 2024.
  8. Kumar A, Chithanna S, Li Y, Zhang X, Dodean RA, Caridha D, Madejczyk MS, Lee PJ, Jin X, Chetree R, Blount C, Dennis WE, DeLuca J, Vuong C, Pannone K, Dinh HT, Leed S, Roth A, Reynolds KA, Kelly JX, Kancharla P. Optimization of B-ring functionalized antimalarial tambjamines and prodiginines. Journal of Medicinal Chemistry, 2024, 67, 19755–19776. October 19, 2024.
  9. Kancharla P, Ortiz D, Fargo CM, Zhang X, Li Y, Sanchez M, Kumar A, Yeluguri M, Dodean RA, Caridha D, Madejczyk MS, Martin M, Jin X, Blount C, Chetree R, Pannone K, Dinh HT, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Dennis WE, Roncal N, Pybus BS, Lee PJ, Roth A, Reynolds KA, Kelly JX, Landfear SM.  Discovery and optimization of tambjamines as a novel class of antileishmanial agents. Journal of Medicinal Chemistry, 2024, 67, 8323-8345; May 9, 2024.
  10. Kancharla P, Li Y, Yeluguri M, Dodean R, Reynolds K, Kelly J. Total synthesis and antimalarial activity of 2-(p-hydroxybenzyl)-prodigiosins, isoheptylprodigiosin, and geometric isomers of tambjamine MYP1 isolated from marine bacteria. Journal of Medicinal Chemistry, 2021, 64, 8739–8754; June 10, 2021.
  11. Alday, PH, McConnell, EV, Zarella Boitz, JM, Dodean, RA, Kancharla P, Kelly, JX, Doggett JS. Acridones are highly potent inhibitors of Toxoplasma gondii tachyzoites. ACS Infectious Diseases. 2021, 7, 1877–1884; March 16, 2021.
  12. Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. Lead optimization of second-generation acridones as broad-spectrum antimalarials. Journal of Medicinal Chemistry, 2020, 63, 6179−6202; May 11, 2020.
  13. Kancharla P, Dodean RA, Li Y, Kelly JX. Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones. RSC Advances, 2019, 9, 42284−42293; December 20, 2019.
  14. Dodean RA, Kancharla P, Li Y, Melendez V, Read L, Bane C, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong T.-L, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Huezo S, Rasmussen S, Stephens M, Tan J, Cooper R, Smilkstein MJ, Pou S, Winter RW, Riscoe MK, Kelly JX. Discovery and structural optimization of acridones as broad-spectrum antimalarials. Journal of Medicinal Chemistry, 2019, 62, 3475–3502; March 10, 2019.
  15. Lu W, Kancharla P, Reynolds KA. MarH, a bifunctional enzyme involved in the condensation and hydroxylation steps of the marineosin biosynthetic pathway. Organic Letters 2017, 19, 1298−1301; March 8, 2017.
  16. Kancharla P, Bonnett SA, Reynolds KA. Stenotrophomonas maltophilia OleC catalyzed ATP-dependent formation of long-chain Z-olefins from 2-alkyl-3-hydroxyalkanoic acids. ChemBioChem 2016, 17, 1426−1429; May 30, 2016.
  17. Kancharla P, Kelly JX, Reynolds KA. Synthesis and structure–activity relationships of tambjamines and B-ring functionalized prodiginines as potent antimalarials. Journal of Medicinal Chemistry 2015, 58, 7286−7309; August 25, 2015.
  18. Kancharla P, Lu W, Salem SM, Kelly JX, Reynolds KA. Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues, and conversion to antimalarial premarineosins via a novel Rieske Oxygenase MarG catalyzed bicyclization. Journal of Organic Chemistry 2014, 79, 11674−11689; November 7, 2014.
  19. Salem SM, Kancharla P, Florova G, Gupta S, Lu W, Reynolds KA. Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster. Journal of the American Chemical Society 2014, 136, 4565−4574; February 27, 2014.
  20. Shivahare R, Korthikunta V, Chandasana H, Suthar MK, Agnihotri P, Vishwakarma P, Chaitanya TK, Kancharla P, Khaliq T, Gupta S, Bhatta RS, Pratap JV, Saxena JK, Gupta S, Tadigoppula N. Synthesis, structure-activity relationships and biological studies of chromenochalcones as potential antileishmanial agents. Journal of Medicinal Chemistry 2014, 57, 3342−3357; March 17, 2014.
  21. Kancharla P, Reynolds KA. Synthesis of 2,2'-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines. Tetrahedron 2013, 69, 8375−8385; July 26, 2013.
  22. Bonnett SA, Whicher JR, Kancharla P, Florova G, Smith JL, Reynolds KA. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene. Chemistry & Biology 2013, 20, 772−783; June 20, 2013.
  23. Tadigoppula N, Korthikunta V, Gupta S, Kancharla P, Khaliq T, Soni A, Srivastava RK, Srivastava K, Puri SK, Raju KS, Wahajuddin, Sijwali PS, Kumar V, Mohammad IS.  Synthesis and insight into the structure–activity relationships of chalcones as antimalarial agents. Journal of Medicinal Chemistry 2013, 56, 31−45; December 10, 2012.
  24. Narender T, Venkateswarlu K, Madhur G, Kancharla P. Highly efficient and selective deprotection method for prenyl, geranyl and phytyl ethers and esters using boron trifluoride-etherate. Synthetic Communications 2013, 43, 26−33; January 20, 2012.
  25. Kancharla P, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry 2011, 54, 5296−5306; July 8, 2011.
  26. Bonnett SA, Kancharla P, Higgins S, del Cardayre S, Reynolds KA. Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in stenotrophomonas. Biochemistry 2011, 50, 9633−9640; September 29, 2011.
  27. Narender T, Madhur G, Dharamsheela, Kancharla P, Sarkar S, Sarkar J, Tripathi RK. One-pot synthesis of cationic amphiphiles from n-alcohols and allyl alcohols. Synlett 2011, 1687−1692; July 5, 2011.
  28. Narender T, Kancharla P, Tiwari S. H2SO4-promoted synthesis of (E)-stilbenes from substituted phenylacetones and substituted benzaldehydes through tandem Aldol–Grob reaction. Synthetic Communications 2011, 41, 1572−1583; April 20, 2011.
  29. Narender T, Kancharla P, Singh VK, Rajendar K, Sarkar J. An unprecedented biogenetic type chemical synthesis of 1(15→11) abeotaxanes from normal taxanes. Journal of Natural Products 2010, 73, 747−750; March 19, 2010.
  30. Kancharla P, Bid HK, Nayak VL, Chaudhary P, Chaturvedi JP, Arya KR, Konwar R, Narender T. In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity. European Journal of Medicinal Chemistry 2009, 44, 3947−3953; April 22, 2009.
  31. Narender T, Kancharla P, Madhur G. Synthesis of (E)-stilbenes and (E,E)-1,4-diphenylbuta-1,3-diene promoted by borontrifluoride-diethyl  ether complex. Synthesis 2009, 3791−3796; September 23, 2009.
  32. Kancharla P, Singh AB, Puri A, Srivastava AK, Narender T. Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity. Bioorganic & Medicinal Chemistry Letters 2009, 19, 4463−4466; May 15, 2009.
  33. Khaliq T, Misra P, Gupta S, Kancharla P, Kant R, Maulik PR, Dube A, Narender T. Peganine hydrochloride dihydrate an orally active antileishmanial agent. Bioorganic & Medicinal Chemistry Letters 2009, 19, 2585−2586; March 16, 2009.
  34. Narender T, Kancharla P, Madhur G. NaOAc mediated selective deprotection of aromatic acetates and its application in the synthesis of natural products. Synthetic Communications 2009, 39, 1949−1956; April 27, 2009.
  35. Narender T, Kancharla P, Shweta. BF3.OEt2 mediated one-pot synthesis of acetylchromans from polyhydroxyacetophenones and isoprene/allyl alcohol. Synthetic Communications 2009, 39, 384−394; January 8, 2009.
  36. Narender T, Kancharla P, Kumar B. BF3.OEt2 mediated regioselective deacetylation of polyacetoxyacetophenones and its application in the synthesis of natural products. Tetrahedron Letters 2008, 49, 4409−4415; May 9, 2008.
  37. Narender T, Kancharla P, Shweta, Srivastava K, Mishra DK, Puri SK. Total synthesis of munchiwarin, a triprenylated chalcone from crotalaria medicagenia. Organic Letters 2007, 9, 5369−5372; November 22, 2007.
  38. Narender T, Kancharla P. BF3.OEt2 mediated biogenetic type synthesis of chromanochalcones from prenylated chalcones via a regioselective cyclization reaction. Tetrahedron Letters 2007, 48, 7628−7632; September 4, 2007.
  39. Narender T, Kancharla P. A simple and highly efficient method for the synthesis of chalcones by using borontrifluoride-etherate. Tetrahedron Letters 2007, 48, 3177−3180; March 12, 2007.
  40. Narender T, Shweta S, Tiwari P, Kancharla P, Khaliq T, Prathipati P, Puri A, Srivastava AK, Chander R, Agarwal SC, Raj K. Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. Bioorganic & Medicinal Chemistry Letters 2007, 17, 1808−1811; December 15, 2006.
  41. Narender T, Khaliq T, Shweta, Kancharla P, Sharma RK. Occurrence, biosynthesis, biological activity and NMR spectroscopy of D and B, D ring seco-limonoids of meliaceae family. Natural Product Communications. 2007, 2, 203; February 1, 2007.

Patents

1. Kancharla P, Kelly JX, Reynolds KA. Tambjamines and B-ring functionalized prodiginines. 
   (WO 2016176450 A1); March 11, 2016.

2. Kancharla P, Dodean R, Kelly JX. Acridone prodrugs for prevention and treatment of malaria.    
Provisional Patent Application No. 63/788,320. April 14, 2025.

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