Iwata-Reuyl Lab Members

Headshot of Dirk Iwata-Reuyl, he is a white man with short grey hair and a beard and mustache. He is wearing a black backpack, a grey t-shirt, and clear framed glasses. He is smiling and leaning forward towards the camera with water as a backdrop.

Dr. Dirk Iwata-Reuyl

Professor of Chemistry
Ph.D. | The Johns Hopkins University, 1992
Post-Doctoral Research Fellow 1992-1994, University of Utah

503-725-5737
iwatareuyld@pdx.edu
Research Lab Homepage

Research Interests

Dr. Iwata-Reuyl's research interests focus on problems at the interface of chemistry and biology, and address diverse aspects of protein function, mechanism, structure, evolution, and design. His group employs a multidisciplinary approach that includes enzymology, kinetics, molecular biology, and organic synthesis, and a network of close collaborations allow them to further broaden the scope of their work to include structural biology, computational genomics, genetics, and physiology.


The inspiration for all the research in the lab is the post-transcriptional processing of RNA, specifically the phenomena of nucleoside modification in the maturation of transfer and ribosomal RNA. These processes result in the generation of a rich mosaic of structurally modified nucleosides, and his research group is working to discover the biological roles of nucleoside modification, elucidate the biosynthetic pathways responsible for the formation of these fascinating molecules, and understand the biochemistry of the enzymes making up the pathways. Recently this work has led to the discovery of novel pathways responsible for nucleoside modification of DNA, and his group is actively engaged in studying these systems.
 

Group Members

Professional photo of Andrew Buckley, a white bald man with a black beard and mustache. He is wearing a grey t-shirt and smiling, open-mouthed, in front of a backdrop of trees and shrubbery in a forested setting.

Andrew Buckley

PhD Candidate

As a member of the Iwata-Reuyl research group, I study the DpdC-catalyzed conversion of dPreQ0 to dADG – two structurally complex modified nucleosides found in DNA. Prior to joining the PSU Chemistry Department, I was a graduate student at CSULB where I attempted to incorporate unnatural amino acids into peptides via SPPS. While a Geology/Paleobiology undergraduate at UCLA, I developed an interest in astrobiology that has guided my academic decisions and career plans ever since.

Photo of Samanthi

Samanthi Herath Gedara

PhD Candidate

Samanthi is a graduate student in the Iwata-Reuyl lab. Her primary research focus is understanding the formation of 7-deazaguanine based DNA modifications. She is also the graduate assistant in the PSU's Bioanalytical Mass Spectral Facility. Her primary duties include LC-MS/MS instrumentation, assisting training for new users, and assisting investigators with projects involving LC-MS. Samanthi is originally from Sri Lanka. She graduated with a BS in chemistry from Georgia College & State University. She earned her MS in chemistry from Eastern Michigan University. She worked in a biotech company and a pharmaceutical company, before joining the PSU chemistry department as a graduate student. In her free time, she enjoys spending time with her family, cooking Sri Lankan dishes, and traveling.
 

Dan Khazaei, a light-skinned man with short dark hair, is looking directly to camera.

Danesh (Dan) Khazaei

PhD Candidate

Dan is a first-year graduate student in the Iwata-Reuyl lab, where he is currently investigating the chemistry and function of the DNA-binding protein DpdB. After earning his B.S. in Biochemistry and Molecular Biology from Linfield University, Dan returned to Portland to pursue his doctoral studies in biochemistry. Outside of the lab, he enjoys staying active, spending time with friends and family, and learning new languages. 
 

 

Aaron Mbwirire, a black man with black hair, standing in front of a street in Portland.

Aaron Mbwirire

PhD Candidate

Aaron Mbwirire (he/him) is a member of the Iwata-Reuyl research group, his current studies  focus on understanding the chemical mechanisms and sequence-specificity of bacteriophage 7-Deazaguanine-based DNA modification systems to elucidate its chemistry that differentiates it from bacterial DNA modifications systems. He graduated with a BSc in Applied Biology and Biochemistry, worked on drug combinations that attain fractional inhibitory concentrations against UTI causing bacteria. He furthered studies attaining a MSc in Applied Microbiology and Biotechnology, researching on metal- tolerant bacteria and chromium bioremediation. 

Photo of Erik Scheleen

Erik Scheleen

PhD Candidate

Erik Scheleen (he/him) is a chemistry Ph.D. in the Dr. Iwata-Reuyl research group. His research is focused on understanding enzyme substrate recognition and the enzymatic mechanism of the threonylcarbamoyl adenosine modification of tRNA. His background is varied with over 5 years of experience in software development including backend development as well as an undergraduate degree in renewable energy engineering with a primary focus on power systems and controls.

Lab Alumni

 

Brennan Farrell 

M.S. Chemistry | Portland State University, 2021

Dr. Benedict Smail

Ph.D. Chemistry | Portland State University, 2019

Dr. Benjamin Turner

Ph.D. Chemistry | Portland State University, 2017

Dr. Adriana Bon Ramos

Ph.D. Chemistry | Portland State University, 2016

Dr. Christopher Deutsch

Ph.D. Chemistry | Portland State University, 2016

Dr. Vimbai Chikwana

Ph.D. Chemistry | Portland State University, 2011

Dr. Shilah Bonnett

Ph.D. Chemistry | Portland State University, 2007

Dr. Bobby W. K. Lee

Ph.D. Chemistry | Portland State University, 2007

Rowaida al-Eryani

M.S. Chemistry | Portland State University, 2007

Vesna Persun

M.S. Chemistry | Portland State University, 2005

Dr. Steve Van Lanen

Ph.D. Chemistry | Portland State University, 2003

Priya K. Siva

M.S. Chemistry | Portland State University, 2003

Mike Beardall 

M.S. Chemistry | Portland State University, 2001

Dr. Sylvia Daoud Kinzie

M.S. Chemistry | Portland State University, 2000

Ph.D. | UCLA, 2005