Research Interests:
Ubiquitin Signaling
Jeffrey Singer joined the PSU Biology faculty in 2008. He also teaches part-time at OHSU’s Department of Biochemistry and Molecular Biology and is a member of the Knight Cancer Institute, Cancer Biology Program at OHSU. His research focuses on regulation of ubiquitin signaling and how it controls essential cell processes such as cell cycle progression, secretion, neuronal function and transcription. He has published and coauthored at least twenty-five articles in peer-reviewed journals and has also authored a number of book chapters and abstracts. He has received numerous grants and has presented extensively. He is a faculty mentor to undergraduates, graduates, and post-doctoral fellows.
Current Projects:
- Role of ubiquitin in ASD
- Cancer of the mammary gland
- Regulation of cyclin E levels by proteolysis
Selected Works:
- Cummings, C., and Singer, J.D. (2021). Cul3 is Required for Normal Development of the Mammary Gland. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03456-1.
- Davidge, B., Rebola, K.G. de O., Agbor, L.N., Sigmund, C.D. and Singer, J.D. (2019). Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E. Journal of Cell Science 132(21): jcs233049.
- Agbor, L.N., Nair, A.R., Wu, J., Lu, K-T., Davis, D.R., Keen, H.L., Quelle, F.W., McCormick, J.A., Singer, J.D. and Curt D. Sigmund (2019) Conditional Deletion of Smooth Muscle Cullin-3 Causes Severe Progressive Hypertension. JCI Insight 4(14): 1-18.
- McCormick, J.A., Yang, C-L., Davidge, B., Zhang, C., Terker, A., Yarborough, B., Meermeier, N.P., Park H-J., McCully, B., West, M., Paliege, A., Bachmann, S., Ellison, D.H., and Jeffrey D. Singer. (2014) Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3. Journal of Clinical Investigation. 124(11): 1-15.
- Wimuttisuk, W, West, M., Davidge, B., Yu, K., Salomon, A., and Singer, J.D. (2014). Novel Cul3 binding proteins function to remodel E3 ligase complexes. BMC Cell Biol. 15: 28-45.