Dr. Jiao is committed to mentoring and developing new reseachers. In addition to managing an REU site, Dr. Jiao's lab provides a wide range of opportunities for both graduate and undergraduate research. Some of the projects currently under way are:
- Nanoparticulate Adjuvants and Delivery Systems Towards New Generation Vaccines: Vaccination has greatly impacted global public health by controlling and preventing infectious diseases and treating cancers. However, it remains difficult to generate sufficient immunity with vaccines containing insufficient immunogenic antigens. To amplify the interaction between antigens and the immune system, we recently reported that antigen coupled to alumina nanoparticles is 500 times more efficiently processed by dendritic cells for major histocompatibility complex (MHC) class I antigen presentation, and elicits strong cytotoxic T cell response against cancer in vivo (Nature Nanotechnology, 2011, 6,645-50). We now extend these studies to infectious disease, with the goal of utilizing alumina NPs to elicit cytotoxic T cell response to defined pathogen antigens. Current student researchers: Kavita Meduri (graduate), Shree C. Aier (undergraduate); previous student researcher: Lester Lampert (graduate)
See the list of publications for more information about past projects.