Research Interests:
DNA Repair, DNA replication, Genome Stability
Justin Courcelle's research lab focuses upon the fundamental "rules" which operate to maintain genomic stability in the cell. During cellular replication, whether in bacterial or human cells, each chromosome is processively replicated in its exact linear order until the precise point when the genomic template has been duplicated. As a cancer biologist, he is interested in how this fundamentally conserved process is regulated and maintained. Through these studies, he also hopes to understand the molecular events which can lead this normally faithful process of duplication to sometimes become less than perfect.
Selected Works:
- SbcC-SbcD and ExoI process convergent forks to complete chromosome replication. Wendel BM, Cole JM, Courcelle CT, Courcelle J. Proc Natl Acad Sci U S A. 2018; 115:349-354. doi: 10.1073/pnas.1715960114.
- Completion of DNA replication in Escherichia coli. Wendel BM, Courcelle CT, Courcelle J. Proc Natl Acad Sci U S A. 2014; 111:16454-9. doi: 10.1073/pnas.1415025111.
- DNA damage-induced replication fork regression and processing in Escherichia coli. Courcelle J, Donaldson JR, Chow KH, Courcelle CT. Science. 2003; 299:1064-7. doi: 10.1126/science.1081328.
- RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli. Courcelle J, Hanawalt PC. Mol Gen Genet. 1999; 262:543-51. doi: 10.1007/s004380051116.
- More publications