Computational & Data Science Seminar
Friday, May 25, 2018 - 12:30pm

What: Computational & Data Science Seminar


When: 12:30 pm May 25th, 2018


Where: Cramer Hall 418

Title:  Mechanistic modeling in biochemistry and cell biology: Successes and challenges
Abstract: Computer simulations have been attempting to probe molecular-scale behavior for 40 years with a mix of failure and success.  This talk will attempt to provide the ‘big picture’ of modeling at molecular and cellular scales, accompanied by specific examples from the speaker’s research program. The focus will be on mechanistic modeling, grounded in the principles of physics and chemistry, as opposed to primarily statistical data analysis. We will explore what mechanistic models are, how they are made, and how they are used. We will consider methods that attempt to literally simulate nature with approaches capable of obtaining key information faster than direct simulation. We will also touch on how physical principles can guide analysis of simulation and experimental data at molecular and cellular scales. Examples will include some of the following: protein folding, virus capsid assembly, ATP synthesis, and cancer-cell behavior.
Bio:  Daniel M. Zuckerman is a biophysicist working on molecular- to cell-scale simulation and data analysis methods, and is currently Professor of Biomedical Engineering at Oregon Health & Science University. The Zuckerman research group uses computations based on the methods of statistical physics to study non-equilibrium and equilibrium processes that take in place in the cell including molecular fluctuations, ligand binding, protein folding, free energy use in molecular machines, virus capsid assembly, and the dynamics of signaling molecules in cancer cells. Before moving to OHSU in 2016, Prof. Zuckerman was a faculty member in the Department of Computational & Systems Biology at the University of Pittsburgh for 14 years.
Following the talk, at 1:30, in the same room:
There will be an informal discussion with the speaker on the general subject of computational science and data science, and how they support and enable science in general.
For more info about the overall seminar series:
To add this seminar to your calendar:  calendar link
Please forward this announcement to students and colleagues whom you think might be interested in this seminar series.Thanks!
Wayne Wakeland and Bruno Jedynak