The Maseeh Mathematics and Statistics Colloquium Series* presents
by Terry Speed, Ph.D., University of California, Berkley, Department of Statistics
Friday, January 31st, 2014 at 3:15pm
Cramer Hall room 171
Refreshments served at 2:30PM in NH 344
This event is free and open to the public
CpG methylation is a mitotically heritable epigenetic mark on DNA which plays a key role in genomic imprinting, X-inactivation, transcriptional regulation, tissue specificity and carcinogenesis. What is co-methylation? Loosely, it is the persistence of the methylated (M) or unmethylated (U) state along a chromosome. Slightly more precisely, it is the association between the methylation state at nearby CpGs, as a function of their separation. "Co-" here is meant to bring to mind correlation. This talk will summarize some results concerning co-methylation we obtained by analysing publicly available sequence data on whole genome bisuplhite-treated DNA. Our immediate goal was to see whether we can simulate whole-genome methylation data that is indistinguishable from the real thing. I'll explain why we want to do this. It turns out to be quite hard (for us).
Terry Speed and Peter Hickey,
Walter & Eliza Hall Institute of Medical Research Australia
* Sponsored by the Maseeh Mathematics and Statistics Colloquium Series Fund and the Fariborz Maseeh Department of Mathematics & Statistics, PSU.